Title : Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity.

Pub. Date : 2012 Apr 13

PMID : 22500608






2 Functional Relationships(s)
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1 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol latexin Homo sapiens
2 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol latexin Homo sapiens