Title : Inhibition of pro-protein convertase subtilisin kexin 9 [corrected] (PCSK-9) as a treatment for hyperlipidaemia.

Pub. Date : 2012 May

PMID : 22493980






1 Functional Relationships(s)
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1 AREAS COVERED: As PCSK-9 binds to the LDLR, a number of approaches involving small molecule or peptide inhibition of binding, antibody-mediated inactivation of binding and the use of antisense oligonucleotides are being investigated as therapeutic approaches to lower LDL-C in man. Oligonucleotides proprotein convertase subtilisin/kexin type 9 Homo sapiens