Title : Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.

Pub. Date : 2012

PMID : 22479513






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study we demonstrate that TRIM21 is tyrosine phosphorylated following TLR3 and TLR4 stimulation, suggesting that its activity is potentially regulated by tyrosine phosphorylation. Tyrosine toll like receptor 3 Homo sapiens
2 In this study we demonstrate that TRIM21 is tyrosine phosphorylated following TLR3 and TLR4 stimulation, suggesting that its activity is potentially regulated by tyrosine phosphorylation. Tyrosine toll like receptor 3 Homo sapiens
3 Our data demonstrates a novel role for tyrosine phosphorylation in regulating the activity of TRIM21 downstream of TLR3 and TLR4. Tyrosine toll like receptor 3 Homo sapiens