Title : Molecular level interaction of inositol hexaphosphate with the C2B domain of human synaptotagmin I.

Pub. Date : 2012 May 1

PMID : 22475172






4 Functional Relationships(s)
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1 Molecular level interaction of inositol hexaphosphate with the C2B domain of human synaptotagmin I. Phytic Acid secretoglobin family 2B member 3, pseudogene Homo sapiens
2 To understand the IP6-induced inhibition of exocytosis of secretory vesicles, we determined the three-dimensional structure of the C2B-IP6 complex by nuclear magnetic resonance (NMR). Phytic Acid secretoglobin family 2B member 3, pseudogene Homo sapiens
3 The circular dichroism measurements demonstrated that IP6 can stabilize the C2B molecule. Phytic Acid secretoglobin family 2B member 3, pseudogene Homo sapiens
4 We identified the binding site using (1)H-(15)N heteronuclear single-quantum coherence spectroscopy titration data and determined the structure of the C2B-IP6 complex using multidimensional NMR studies. Phytic Acid secretoglobin family 2B member 3, pseudogene Homo sapiens