Title : Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

Pub. Date : 2012 May 11

PMID : 22464731






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Skp2 interacts with NBS1 and triggers K63-linked ubiquitination of NBS1 upon DSBs, which is critical for the interaction of NBS1 with ATM, thereby facilitating ATM recruitment to the DNA foci for activation. dsbs nibrin Homo sapiens
2 Skp2 interacts with NBS1 and triggers K63-linked ubiquitination of NBS1 upon DSBs, which is critical for the interaction of NBS1 with ATM, thereby facilitating ATM recruitment to the DNA foci for activation. dsbs nibrin Homo sapiens