Title : JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.

Pub. Date : 2012

PMID : 22461904






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The further mechanistic studies showed that JWA deficiency blocked TPA-induced activation of MAPKs and its downstream transcription factor Elk1 both in vitro and in vivo. Tetradecanoylphorbol Acetate ELK1, member of ETS oncogene family Mus musculus
2 JWA(Delta2/Delta2) mice are resistance to tumorigenesis induced by DMBA/TPA probably through inhibition of transcription factor Elk1 via MAPKs. Tetradecanoylphorbol Acetate ELK1, member of ETS oncogene family Mus musculus