Title : HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.

Pub. Date : 2012 May 15

PMID : 22461506






1 Functional Relationships(s)
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1 In addition, loss of ErbB3 impaired Akt and p44/42 phosphorylation in preneoplastic HER2-overexpressing mammary glands and in tumors, decreased growth of preexisting HER2-overexpressing tumors, and improved tumor response to the HER2 tyrosine kinase inhibitor lapatinib. Lapatinib erb-b2 receptor tyrosine kinase 3 Homo sapiens