Title : Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells.

Pub. Date : 2012 Jul 6

PMID : 22455621






2 Functional Relationships(s)
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1 When pretreated with three CCBs before 50 mug/ml ox-LDL stimulation, 30 muM lacidipine and 3 muM amlodipine exhibited 27% and 18% decrease of pro-proliferative effect induced by ox-LDL, whereas (S-)-amlodipine did not have any anti-proliferative effect. lacidipine latexin Homo sapiens
2 30 muM lacidipine inhibited about two-thirds of the ox-LDL induced ROS production in HUVSMCs, whereas amlodipine and (S-)-amlodipine did not have influence on ROS production. lacidipine latexin Homo sapiens