Title : Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.

Pub. Date : 2012 Jun 21

PMID : 22446485






1 Functional Relationships(s)
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1 Notably, shRNA knockdown of Bim, Bak, or Bax, but not Noxa, significantly attenuated obatoclax/sorafenib lethality, whereas ectopic expression of Mcl-1 exerted a protective effect. Sorafenib BCL2 associated X, apoptosis regulator Homo sapiens