Pub. Date : 2010 Feb
PMID : 22443876
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional and association studies on the pig HMGCR gene, a cholesterol-synthesis limiting enzyme. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Sus scrofa |
| 2 | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme in the biosynthesis of cholesterol. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Sus scrofa |
| 3 | The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme in the biosynthesis of cholesterol. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Sus scrofa |
| 4 | We have, additionally, studied the association of one of these polymorphisms (HMGCR:c.807A>C) with several lipid deposition- and cholesterol-related traits in a half-sib population generated from a commercial Duroc line, showing in some families a positive relationship of HMGCR:c.807A allele with serum low-density lipoprotein (LDL)-bound cholesterol and triglyceride levels, and also with intramuscular fat (IMF) content of gluteus medius muscle. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Sus scrofa |
| 5 | We have, additionally, studied the association of one of these polymorphisms (HMGCR:c.807A>C) with several lipid deposition- and cholesterol-related traits in a half-sib population generated from a commercial Duroc line, showing in some families a positive relationship of HMGCR:c.807A allele with serum low-density lipoprotein (LDL)-bound cholesterol and triglyceride levels, and also with intramuscular fat (IMF) content of gluteus medius muscle. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Sus scrofa |
| 6 | The results indicate that HMGCR expression levels in muscle are different in the two groups of pigs with extreme values for fat deposition and total cholesterol levels, and also between animals with the different HMGCR genotypes. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Sus scrofa |