Title : A new continuous fluorometric assay for acetylcholinesterase activity and inhibitor screening with emissive core-shell silica particles containing tetraphenylethylene fluorophore.

Pub. Date : 2012 May 7

PMID : 22430667






4 Functional Relationships(s)
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1 The reaction kinetic parameters for AChE were successfully estimated with the silica particles and 2. Silicon Dioxide acetylcholinesterase (Cartwright blood group) Homo sapiens
2 These results reveal that the ensemble of the silica particles and 2 can be utilized for AChE assay. Silicon Dioxide acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Moreover, the fluorescence spectra of the ensemble of the silica particles and 2 containing AChE were also measured after further addition of either neostigmine or tacrine which are typical inhibitors of AChE. Silicon Dioxide acetylcholinesterase (Cartwright blood group) Homo sapiens
4 The results manifest that the ensemble of the emissive silica particles and 2 is also useful for screening the inhibitors of AChE. Silicon Dioxide acetylcholinesterase (Cartwright blood group) Homo sapiens