Title : Barium mimics the effect of D-glucose on 86Rb+ fluxes in mouse pancreatic beta-cells.

Pub. Date : 1990 Nov 12

PMID : 2242386






4 Functional Relationships(s)
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1 Furosemide, an inhibitor of Na+, K+, Cl- co-transport, reduced the 86Rb+ influx and the effect was partly additive to the effect of 2 mM Ba2+. Furosemide bone area 2 Mus musculus
2 When the islets were preincubated with Ba2+ (2 mM) the specific effect of 1 mM furosemide on the 86Rb+ influx was reduced, whereas, in acute experiments, Ba2+ (2 mM) did not affect the specific effect of furosemide on 86Rb+ influx. Furosemide bone area 2 Mus musculus
3 When the islets were preincubated with Ba2+ (2 mM) the specific effect of 1 mM furosemide on the 86Rb+ influx was reduced, whereas, in acute experiments, Ba2+ (2 mM) did not affect the specific effect of furosemide on 86Rb+ influx. Furosemide bone area 2 Mus musculus
4 86Rb+ efflux from preloaded islets was significantly reduced by 2 mM Ba2+ and during the first 5 min of ion efflux the effect of the combination of 2 mM Ba2+ and 1 mM furosemide was stronger than the effect of Ba2+ alone. Furosemide bone area 2 Mus musculus