Pub. Date : 2012 Apr 15
PMID : 22422888
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we examined the role of IRF5 in the pathogenesis of pristane-induced lupus in mice. | pristane | interferon regulatory factor 5 | Mus musculus |
| 2 | The pathological response to pristane in IRF5(-/-) mice shared many features with type I IFN receptor (IFNAR)(-/-) and TLR7(-/-) mice: production of anti-Sm/RNP autoantibodies, glomerulonephritis, generation of Ly6C(hi) monocytes, and IFN-I production all were greatly attenuated. | pristane | interferon regulatory factor 5 | Mus musculus |
| 3 | Lymphocyte activation following pristane injection was greatly diminished in IRF5(-/-) mice, and Th cell differentiation was deviated from Th1 in wild-type mice toward Th2 in IRF5(-/-) mice. | pristane | interferon regulatory factor 5 | Mus musculus |
| 4 | Collectively, these data indicate that altered production of IFN-I and other cytokines in IRF5(-/-) mice prevents pristane from inducing lupus pathology by broadly affecting T and B lymphocyte activation/differentiation. | pristane | interferon regulatory factor 5 | Mus musculus |