Title : Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer.

Pub. Date : 2012 Mar 15

PMID : 22420423






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer. Mitomycin tumor protein p53 Homo sapiens
2 CONCLUSIONS: Our data indicate loss of function of the ATM-Chk2-p53 cascade to be strongly associated with resistance to anthracycline/mitomycin-containing chemotherapy in breast cancer. Mitomycin tumor protein p53 Homo sapiens