Pub. Date : 1990 Sep 15
PMID : 2241897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT). | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 2 | The cytotoxic response of the human large cell lung carcinoma line NCI H157 to exposure to the polyamine analogue N1 N12-bis(ethyl)spermine (BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT). | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 3 | Although other acetylases are capable of acetylating polyamines using acetyl-CoA as the acetyl donor, the greater than 600-fold induction within 24 h was found to be specifically SSAT, since essentially all activity was precipitable by the specific antisera. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 4 | The large cell lung carcinoma line NCI H157 represents a useful system to produce large amounts of the SSAT protein and to study the molecular events responsible for the induction and control of this important polyamine-metabolic enzyme. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |