Title : The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress.

Pub. Date : 2012 Jun 1

PMID : 22417654






1 Functional Relationships(s)
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1 In the present study, we used biochemical and molecular approaches to isolate and link the serine/threonine PP2A (protein phosphatase 2A) holoenzyme containing the B55alpha regulatory subunit, with nuclear import of FOXO1 in pancreatic islet beta-cells under oxidative stress, a condition associated with cellular dysfunction in Type 2 diabetes. Serine forkhead box O1 Rattus norvegicus