Title : Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.

Pub. Date : 2013 Jan 10

PMID : 22410783






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In comparison, SHD cells immortalized by the powerful polycyclic hydrocarbon carcinogen benzo(a)pyrene display transversion point mutations in the DNA-binding domain of p53 coupled with INK4 alterations such as loss of expression of p15. Benzo(a)pyrene tumor protein p53 Homo sapiens