Title : Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy.

Pub. Date : 2012 May 1

PMID : 22407832






1 Functional Relationships(s)
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1 RESULTS: The addition of lapatinib to INK-128 prevented both HER2 and HER3 phosphorylation induced by INK-128, resulting in inhibition of both PI3K/Akt/mTOR and ERK pathways. Lapatinib erb-b2 receptor tyrosine kinase 3 Homo sapiens