Title : Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the α2A adrenergic receptor.

Pub. Date : 2012 Mar 30

PMID : 22405824






3 Functional Relationships(s)
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1 Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. Desipramine adrenoceptor alpha 2A Homo sapiens
2 We have recently identified the tricyclic antidepressant drug desipramine (DMI) as a direct ligand at the alpha(2A) adrenergic receptor (AR) without itself driving heterotrimeric G protein/downstream effector activation [5]. Desipramine adrenoceptor alpha 2A Homo sapiens
3 We have recently identified the tricyclic antidepressant drug desipramine (DMI) as a direct ligand at the alpha(2A) adrenergic receptor (AR) without itself driving heterotrimeric G protein/downstream effector activation [5]. Desipramine adrenoceptor alpha 2A Homo sapiens