Pub. Date : 2012 Apr 3
PMID : 22404107
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation. | Superoxides | aldehyde oxidase 1 | Homo sapiens |
| 2 | Utilizing electron paramagnetic resonance spin trapping, we measured the role of AO in the generation of reactive oxygen species (ROS) through the oxidation of NADH and the effects of inhibitors of AO on NADH-mediated superoxide (O(2)( -)) generation. | Superoxides | aldehyde oxidase 1 | Homo sapiens |
| 3 | With NADH oxidation by AO, >=65% of the total electron flux led to O(2)( -) generation. | Superoxides | aldehyde oxidase 1 | Homo sapiens |
| 4 | Diphenyleneiodonium completely inhibited AO-mediated O(2)( -) production, confirming that this occurs at the FAD site. | Superoxides | aldehyde oxidase 1 | Homo sapiens |
| 5 | From the kinetic data, and the levels of AO and NADH, O(2)( -) production was estimated to be ~89 and ~4 nM/s in liver and heart, respectively, much higher than that estimated for XOR under similar conditions. | Superoxides | aldehyde oxidase 1 | Homo sapiens |