Title : Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.

Pub. Date : 2012 Mar 7

PMID : 22397316






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We have previously shown that the RhoA/Rho kinase (ROCK) pathway is misregulated in cellular and animal SMA models, and that inhibition of ROCK with the chemical Y-27632 significantly increased the lifespan of a mouse model of SMA. Y 27632 Rho-associated coiled-coil containing protein kinase 2 Mus musculus
2 We have previously shown that the RhoA/Rho kinase (ROCK) pathway is misregulated in cellular and animal SMA models, and that inhibition of ROCK with the chemical Y-27632 significantly increased the lifespan of a mouse model of SMA. Y 27632 Rho-associated coiled-coil containing protein kinase 2 Mus musculus
3 We have previously shown that the RhoA/Rho kinase (ROCK) pathway is misregulated in cellular and animal SMA models, and that inhibition of ROCK with the chemical Y-27632 significantly increased the lifespan of a mouse model of SMA. Y 27632 Rho-associated coiled-coil containing protein kinase 2 Mus musculus