Pub. Date : 2012 Jun
PMID : 22392284
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |
| 2 | However, very few studies regarding the effects of acrylamide on cytochrome P450 and Glutathione S-Transferase (GST) isozymes have been pursued. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |
| 3 | However, very few studies regarding the effects of acrylamide on cytochrome P450 and Glutathione S-Transferase (GST) isozymes have been pursued. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |
| 4 | The aim of this study is to elucidate the effects of acrylamide on cytochrome P450 and GST isozymes in HepG2 cell line. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |
| 5 | In addition, GST-mu activity was increased 2.4- and 5.1-fold by acrylamide. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |
| 6 | Moreover, GST-mu mRNA and protein levels increased twofold as a result of acrylamide treatment. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |
| 7 | In conclusion, human cell exposure to acrylamide causes an increase in the levels of carcinogenicity and toxicity and a disturbance in drug metabolism, possibly due to complex effects on P450 and GST isozymes. | Acrylamide | glutathione S-transferase kappa 1 | Homo sapiens |