Pub. Date : 2012 Apr
PMID : 22381691
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of MRP8/14 was also elevated in EC exposed to high glucose conditions. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 2 | EC function was impaired by high glucose concentrations, and this effect could be mimicked by MRP8 over-expression. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 3 | MRP8 knockdown by shRNA significantly restored EC function after exposure to high glucose concentrations. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 4 | MRP8 expression in glucose exposed cells was also inhibited using pharmacological blockade of glucose-induced pathways. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 5 | MRP8 expression in glucose exposed cells was also inhibited using pharmacological blockade of glucose-induced pathways. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 6 | CONCLUSIONS: EC dysfunction caused by elevated glucose levels could be mimicked by MRP8/14 over-expression and reversed/prevented by MRP8 knockdown. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |
| 7 | CONCLUSIONS: EC dysfunction caused by elevated glucose levels could be mimicked by MRP8/14 over-expression and reversed/prevented by MRP8 knockdown. | Glucose | ATP binding cassette subfamily C member 8 | Homo sapiens |