Pub. Date : 2012 Apr 12
PMID : 22380603
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sildenafil inhibits cGMP efflux by binding to ABCC5, and in order to search for potential novel ABCC5 inhibitors, we have identified sildenafil derivates using structural and computational guidance and tested them for the cGMP efflux effect. | Sildenafil Citrate | ATP binding cassette subfamily C member 5 | Homo sapiens |
| 2 | Seven of 11 compounds predicted by VLS to bind to ABCC5 were more potent than sildenafil, and the two most potent showed K(i) of 50-100 nM. | Sildenafil Citrate | ATP binding cassette subfamily C member 5 | Homo sapiens |