Title : Mimosine arrests the cell cycle prior to the onset of DNA replication by preventing the binding of human Ctf4/And-1 to chromatin via Hif-1α activation in HeLa cells.

Pub. Date : 2012 Feb 15

PMID : 22374673






1 Functional Relationships(s)
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1 Here, we show that mimosine interrupts the binding of Ctf4 to chromatin, which is essential for the initiation of DNA replication in HeLa cells, and this effect is mediated by the Hif-1alpha-dependent increase in the level of p27. Mimosine interferon alpha inducible protein 27 Homo sapiens