Title : Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205.

Pub. Date : 2012 Mar 15

PMID : 22356767






1 Functional Relationships(s)
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1 Metformin-induced SIS in BJ-1 fibroblasts was accompanied by the striking activation of several microRNAs belonging to the miR-200s family (miR-200a, miR-141 and miR429) and miR-205, thus mimicking a recently described ability of ROS to chemosensitize cancer cells by specifically upregulating anti-EMT (epithelial-to-mesenchymal transition) miR-200s. Metformin IL2 inducible T cell kinase Homo sapiens