Title : Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.

Pub. Date : 2012 Apr 6

PMID : 22354966






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Endothelium-specific deletion of RGS2 had little effect on NO-dependent relaxation but markedly impaired EDHF-dependent relaxation. edhf regulator of G protein signaling 2 Homo sapiens
2 RGS2 deficiency enables endothelial G(i/o) activity to inhibit EDHF-dependent relaxation, whereas RGS2 sufficiency facilitates EDHF-evoked relaxation by squelching endothelial G(i/o) activity. edhf regulator of G protein signaling 2 Homo sapiens
3 Mutation or down-regulation of RGS2 in hypertension patients therefore may contribute to endothelial dysfunction and defective EDHF-dependent relaxation. edhf regulator of G protein signaling 2 Homo sapiens