Title : Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation.

Pub. Date : 2012 Apr

PMID : 22354575






3 Functional Relationships(s)
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1 Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation. Fluorescein dynein axonemal heavy chain 8 Homo sapiens
2 A series of fluorescein analogues were first screened against the ATPase activity using the truncated unregulated SecA catalytic domain. Fluorescein dynein axonemal heavy chain 8 Homo sapiens
3 Very importantly, the potency of these fluorescein analogues in inhibiting the truncated SecA ATPase correlates with their ability to inhibit the biologically relevant protein translocation activity of SecA. Fluorescein dynein axonemal heavy chain 8 Homo sapiens