Title : DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.

Pub. Date : 2012 Jul

PMID : 22349266






2 Functional Relationships(s)
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Protein Name
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1 When treated with mitomycin C, p53-deficient cells, but not p53-expressing cells, showed a marked increase in ceramide levels. Mitomycin tumor protein p53 Homo sapiens
2 When inhibition of UGCG and treatment with mitomycin C were combined, p53-deficient, but not p53-expressing cells, showed a significant increase in cell death, suggesting that the regulation of sphingolipid metabolism could be used to sensitize cells to chemotherapeutic drugs. Mitomycin tumor protein p53 Homo sapiens