Pub. Date : 2012 Apr 21
PMID : 22348893
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was designed to evaluate effects of acute ethanol on extracellular signal-regulated kinase phosphorylation (p-ERK1/2) in mesocorticolimbic brain regions. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | We also sought to determine if age-specific effects of ethanol on p-ERK1/2 are associated with ethanol-induced behavioral deficits on acquisition of the hippocampal-dependent novel object recognition (NOR) test. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | We also sought to determine if age-specific effects of ethanol on p-ERK1/2 are associated with ethanol-induced behavioral deficits on acquisition of the hippocampal-dependent novel object recognition (NOR) test. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | Ethanol (1g/kg) selectively reduced p-ERK1/2 IR in the dentate gyrus and increased p-ERK1/2 IR in the BLA only in adolescent mice. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 5 | Ethanol (1g/kg) selectively reduced p-ERK1/2 IR in the dentate gyrus and increased p-ERK1/2 IR in the BLA only in adolescent mice. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 6 | Ethanol (3g/kg) produced the same effects on p-ERK1/2 IR in both age groups with increases in CeA and mPFC, but a decrease in the dentate gyrus, as compared to age-matched saline controls. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 7 | Pretreatment with ethanol (1g/kg) disrupted performance on the NOR test specifically in adolescents, which corresponds with the ethanol-induced inhibition of p-ERK1/2 IR in the hippocampus. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 8 | Pretreatment with ethanol (1g/kg) disrupted performance on the NOR test specifically in adolescents, which corresponds with the ethanol-induced inhibition of p-ERK1/2 IR in the hippocampus. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |
| 9 | Acute ethanol produces a unique set of changes in ERK1/2 phosphorylation in the adolescent brain that are associated with disruption of hippocampal-dependent memory acquisition. | Ethanol | mitogen-activated protein kinase 3 | Mus musculus |