Title : [Bcl-2 inhibitor ABT-737 enhances the cisplatin-induced apoptosis in breast cancer T47D cells].

Pub. Date : 2011 Dec

PMID : 22340096






2 Functional Relationships(s)
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1 The detection of the cleavage of PARP showed that ABT-737 lowered the doses of cisplatin to induce apoptosis and shortened the induction time of apoptosis in T47D cells. Cisplatin collagen type XI alpha 2 chain Homo sapiens
2 Compared with the single use of cisplatin, the combination of ABT-737 and cisplatin accelerated the cleavage of PARP and caspase3, but did not alter the expression levels of Bcl-2, Bcl-X(L), and Bax. Cisplatin collagen type XI alpha 2 chain Homo sapiens