Pub. Date : 2012 May
PMID : 22336948
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The increased abundance and activity of cathelicidin and kallikrein 5 (KLK5), a predominant trypsin-like serine protease (TLSP) in the stratum corneum, have been implicated in the pathogenesis of rosacea, a disorder treated by the use of low-dose doxycycline. | Doxycycline | kallikrein related peptidase 11 | Homo sapiens |
| 2 | Here we hypothesized that doxycycline can inhibit activation of tryptic KLKs through an indirect mechanism by inhibition of matrix metalloproteinases (MMPs) in keratinocytes. | Doxycycline | kallikrein related peptidase 11 | Homo sapiens |
| 3 | However, when doxycycline or other MMP inhibitors were added to live keratinocytes during the production of tryptic KLKs, this treatment indirectly resulted in decreased TLSP activity. | Doxycycline | kallikrein related peptidase 11 | Homo sapiens |
| 4 | However, when doxycycline or other MMP inhibitors were added to live keratinocytes during the production of tryptic KLKs, this treatment indirectly resulted in decreased TLSP activity. | Doxycycline | kallikrein related peptidase 11 | Homo sapiens |
| 5 | Furthermore, doxycycline under these conditions inhibited the generation of the cathelicidin peptide LL-37 from its precursor protein hCAP18, a process dependent on KLK activity. | Doxycycline | kallikrein related peptidase 11 | Homo sapiens |