Title : [The influence of inhibiting notch signal on pulmonary vascular remodeling induced by PDGF].

Pub. Date : 2011 Nov

PMID : 22332538






2 Functional Relationships(s)
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1 The alterations of Notch 1 to 4 receptor and HERP1, 2 mRNA were discerned by FQ-PCR to observe the influence of DAPT on Notch signal. dapt notch receptor 1 Rattus norvegicus
2 When DAPT were added to inhibit Notch signaling, the expression of HERP1, 2 mRNA decreased, the degrees of PDGF induced vascular medial thickness and PCNA positive cell rate increase as well as caspase-3 positive cell rate decrease were all attenuated notably. dapt notch receptor 1 Rattus norvegicus