Title : Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells.

Pub. Date : 2012 May

PMID : 22328572






4 Functional Relationships(s)
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1 Microarray bioinformatics analysis suggested that the signal transducer and activator of transcription 3 (STAT3) pathway could be important in regulating the stemness signature in ATC-CD133+ cells; therefore, the effect of the potent STAT3 inhibitor cucurbitacin I in ATC-CD133+ cells was evaluated in this study. cucurbitacin I signal transducer and activator of transcription 3 Mus musculus
2 Microarray bioinformatics analysis suggested that the signal transducer and activator of transcription 3 (STAT3) pathway could be important in regulating the stemness signature in ATC-CD133+ cells; therefore, the effect of the potent STAT3 inhibitor cucurbitacin I in ATC-CD133+ cells was evaluated in this study. cucurbitacin I signal transducer and activator of transcription 3 Mus musculus
3 Microarray bioinformatics analysis suggested that the signal transducer and activator of transcription 3 (STAT3) pathway could be important in regulating the stemness signature in ATC-CD133+ cells; therefore, the effect of the potent STAT3 inhibitor cucurbitacin I in ATC-CD133+ cells was evaluated in this study. cucurbitacin I signal transducer and activator of transcription 3 Mus musculus
4 Targeting STAT3 with cucurbitacin I in ATC may provide a new approach for therapeutic treatment in the future. cucurbitacin I signal transducer and activator of transcription 3 Mus musculus