Title : Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms.

Pub. Date : 2012 Feb 8

PMID : 22323734






2 Functional Relationships(s)
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1 Nicotine-induced upregulation is the long-lasting increase in nAChR radioligand binding sites in brain resulting from exposure. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus
2 Using live rat cortical neurons, we examined for the first time how exposure and withdrawal of nicotine shape the kinetics of native alpha4beta2-containing nAChR upregulation in real time. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus