Title : Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells.

Pub. Date : 2012 Mar 15

PMID : 22314224






3 Functional Relationships(s)
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1 By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one matrix metallopeptidase 1 Homo sapiens
2 By transient transfection analysis with the MMP-1 promoter (-2846 to -29 nt) and AP-1 promoter, MMP-1 and AP-1 promoter activities were induced by phorbol myristate acetate (PMA) but were significantly inhibited by PD98059 (ERK1/2 inhibitor) or SP600125 (JNK inhibitor). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one matrix metallopeptidase 1 Homo sapiens
3 The induction of MMP-1 and AP-1 promoters by PMA was attenuated by Rh1, and both promoter activities were synergistically inhibited by co-treatment with PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one matrix metallopeptidase 1 Homo sapiens