Title : Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: role of the PSD-95/NR1/nNOS/PKCĪ³ signaling pathway.

Pub. Date : 2012 Apr 15

PMID : 22309983






3 Functional Relationships(s)
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1 On day 5 after drug infusion, increased expression and phosphorylation of spinal membrane NMDAR NR1 subunit and expression of PSD-95 were observed following chronic morphine infusion and these effects were attenuated by amitriptyline co-infusion. Morphine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
2 These findings suggest that the attenuation of morphine tolerance caused by amitriptyline is due to downregulation of NMDAR NR1 subunit expression in the synaptosomal membrane accompanied by decreased expression of the scaffolding protein PSD-95. Morphine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
3 The effects of amitriptyline in attenuating astrocyte activation and reversing tolerance to morphine may be due, at least in part, to inhibition of the PSD-95/NMDAR NR1/nNOS/PKCgamma signaling cascade. Morphine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus