Title : Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.

Pub. Date : 2012 Feb 7

PMID : 22308357






2 Functional Relationships(s)
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1 PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-beta promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes. Poly I-C toll-like receptor adaptor molecule 1 Mus musculus
2 PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-beta promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes. Poly I-C toll-like receptor adaptor molecule 1 Mus musculus