Title : Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex.

Pub. Date : 2012 May

PMID : 22308197






1 Functional Relationships(s)
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1 Using receptor binding studies followed by immunoprecipitation of nAChR subunits, we showed that adolescent nicotine exposure, as compared with saline, caused an increase in mPFC nAChRs containing alpha4 or beta2 subunits (24 and 18%, respectively) 24 h after the last injection. Nicotine cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus