Title : 17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line.

Pub. Date : 2012 May 15

PMID : 22306083






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 17beta-Estradiol (E2) in primary rat pachytene spermatocytes (PS) binds estrogen receptor alpha (ESR1) and GPER to activate EGFR/ERK/c-Jun pathway leading to up regulation of proapoptotic factor bax. Estradiol G protein-coupled estrogen receptor 1 Rattus norvegicus