Pub. Date : 2012 Dec
PMID : 22302604
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor kappaB in rats. | dapt | notch receptor 1 | Rattus norvegicus |
| 2 | Gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-1-alanyl]-S-phenylglycine t-butyl ester (DAPT) suppresses the activation of Notch 1 signaling, which is recognized as the cell fate signaling and may participate in inflammatory processes together with NF-kappaB pathway that contributes to the brain damage after stroke. | dapt | notch receptor 1 | Rattus norvegicus |
| 3 | This study investigated the time course expression of Notch 1 and the effects of DAPT on Notch 1 and NF-jB after MCAO. | dapt | notch receptor 1 | Rattus norvegicus |
| 4 | The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-kappaB and protected brain from damage caused by MCAO. | dapt | notch receptor 1 | Rattus norvegicus |
| 5 | The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-kappaB and protected brain from damage caused by MCAO. | dapt | notch receptor 1 | Rattus norvegicus |
| 6 | These results may indicate that the downregulation of Notch 1-NF-kappaB pathway after ischemia by administration of DAPT is a potential mechanism for its protection. | dapt | notch receptor 1 | Rattus norvegicus |