Pub. Date : 2012 Mar
PMID : 22301935
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Transmembrane protease serine 6 (TMPRSS6) regulates iron homeostasis by inhibiting the expression of hepcidin. | Iron | transmembrane serine protease 6 | Homo sapiens |
| 2 | BACKGROUND: Transmembrane protease serine 6 (TMPRSS6) regulates iron homeostasis by inhibiting the expression of hepcidin. | Iron | transmembrane serine protease 6 | Homo sapiens |
| 3 | Multiple common variants in TMPRSS6 were significantly associated with serum iron in recent genome-wide association studies, but their effects in the Chinese remain to be elucidated. | Iron | transmembrane serine protease 6 | Homo sapiens |
| 4 | DESIGN: The SNPs rs855791(V736A) and rs4820268(D521D) in the TMPRSS6 gene were genotyped and tested for their associations with plasma iron and type 2 diabetes risk in 1574 unrelated Chinese Hans from Beijing. | Iron | transmembrane serine protease 6 | Homo sapiens |
| 5 | RESULTS: The 2 TMPRSS6 SNPs rs855791(V736A) and rs4820268(D521D) were both significantly associated with plasma ferritin (P <= 0.0058), hemoglobin (P <= 0.0013), iron overload risk (P <= 0.0068), and type 2 diabetes risk (P <= 0.0314). | Iron | transmembrane serine protease 6 | Homo sapiens |
| 6 | CONCLUSIONS: These findings suggest that TMPRSS6 variants were significantly associated with plasma ferritin, hemoglobin, risk of iron overload, and type 2 diabetes in Chinese Hans. | Iron | transmembrane serine protease 6 | Homo sapiens |