Title : Impact of efavirenz on intestinal metabolism and transport: insights from an interaction study with ezetimibe in healthy volunteers.

Pub. Date : 2012 Mar

PMID : 22297387






1 Functional Relationships(s)
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1 Efavirenz (single dose) slightly increased ezetimibe absorption and markedly decreased exposure to ezetimibe-glucuronide (single dose and multiple dose), which may be explained by inhibition of UGT1A1 and ABCB1 (in vitro data). efavirenz UDP glucuronosyltransferase family 1 member A1 Homo sapiens