Pub. Date : 1990 Nov 5
PMID : 2229066
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of cultured bovine chromaffin cells with histamine (10(-5) M), nicotine (10(-6) M), and veratridine (2 x 10(-6) M) results in a time-dependent up to 5-fold increase in proenkephalin (Penk) mRNA levels. | Nicotine | proenkephalin | Bos taurus |
| 2 | Stimulation of cultured bovine chromaffin cells with histamine (10(-5) M), nicotine (10(-6) M), and veratridine (2 x 10(-6) M) results in a time-dependent up to 5-fold increase in proenkephalin (Penk) mRNA levels. | Nicotine | proenkephalin | Bos taurus |
| 3 | Similarly, incubation of chromaffin cells with cycloheximide (10(-6) M), given at 0-6 h, blocks the increase in Penk mRNA after stimulation with histamine and nicotine indicating that ongoing protein synthesis is necessary for the delayed rise of Penk mRNA. | Nicotine | proenkephalin | Bos taurus |