Title : Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

Pub. Date : 2012 Mar 23

PMID : 22282497






1 Functional Relationships(s)
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Protein Name
Organism
1 Resistance to atovaquone in the field is associated with point mutations in the Q(o) pocket of cytochrome b, most notably near the conserved Pro(260)-Glu(261)-Trp(262)-Tyr(263) (PEWY) region in the ef loop). Proline mitochondrially encoded cytochrome b Homo sapiens