Title : Mechanisms of inhibition of mononuclear cell activation by the iron-chelating agent desferrioxamine.

Pub. Date : 1990 Oct

PMID : 2228020






2 Functional Relationships(s)
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1 Desferrioxamine rapidly achieved equilibrium across the cell membrane (within 60 min) and chelated 59Fe delivered to activated cells by the transferrin endocytic cycle. Deferoxamine transferrin Homo sapiens
2 In support of a dual effect of the drug is the finding that at 50 mumol/l, desferrioxamine-enhanced expression of the transferrin receptor occurred, an adaptive response made to intracellular iron depletion, while IL-2 receptor expression was inhibited. Deferoxamine transferrin Homo sapiens