Title : CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder.

Pub. Date : 2012

PMID : 22279584






1 Functional Relationships(s)
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1 Lumbar administration of recombinant I2S to enzyme deficient animals reduced the storage of glycosaminoglycans in both superficial and deep brain tissues, with concurrent morphological improvements. Glycosaminoglycans iduronate 2-sulfatase Mus musculus