Title : A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

Pub. Date : 1990 Aug

PMID : 2227414






2 Functional Relationships(s)
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1 Single base substitutions at position +23 that impair Tat-mediated trans-activation in vivo also reduce binding of Tat to TAR in vitro, suggesting that the first uridine residue in the bulge is the critical base for both functions. Uridine tyrosine aminotransferase Homo sapiens
2 Single base substitutions at position +23 that impair Tat-mediated trans-activation in vivo also reduce binding of Tat to TAR in vitro, suggesting that the first uridine residue in the bulge is the critical base for both functions. Uridine tyrosine aminotransferase Homo sapiens