Pub. Date : 2012 Apr 15
PMID : 22268508
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages. | Cyclic AMP | prostaglandin E synthase | Mus musculus |
| 2 | Furthermore, the cAMP signalling pathway co-operates with LPS (lipopolysaccharide) in the induction of COX-2 and mPGES-1 transcriptional activation. | Cyclic AMP | prostaglandin E synthase | Mus musculus |
| 3 | Activation of the PGE2/EP2/PKA signalling pathway induced the phosphorylation of CREB [CRE (cAMP-response element)-binding protein] in macrophages and stimulated the specific binding of this transcription factor to COX2 and mPGES-1 promoters. | Cyclic AMP | prostaglandin E synthase | Mus musculus |