Pub. Date : 2012 Apr
PMID : 22266331
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of serine 212 confers novel activity to human estrogen receptor alpha. | Serine | estrogen receptor 1 | Homo sapiens |
| 2 | Estrogen receptor alpha (ERalpha) can be phosphorylated at various residues, one of which is serine 212 in the DNA binding domain. | Serine | estrogen receptor 1 | Homo sapiens |
| 3 | Estrogen receptor alpha (ERalpha) can be phosphorylated at various residues, one of which is serine 212 in the DNA binding domain. | Serine | estrogen receptor 1 | Homo sapiens |
| 4 | Here, we have investigated the role of phosphorylated serine 212 in the regulation of ERalpha activity by comparing it with serine 236, another potential phosphorylation site within the DNA binding domain, and demonstrated that phosphorylation of serine 212 confers upon ERalpha a distinct activity regulating gene expression in Huh-7 cells. | Serine | estrogen receptor 1 | Homo sapiens |
| 5 | Here, we have investigated the role of phosphorylated serine 212 in the regulation of ERalpha activity by comparing it with serine 236, another potential phosphorylation site within the DNA binding domain, and demonstrated that phosphorylation of serine 212 confers upon ERalpha a distinct activity regulating gene expression in Huh-7 cells. | Serine | estrogen receptor 1 | Homo sapiens |
| 6 | Here, we have investigated the role of phosphorylated serine 212 in the regulation of ERalpha activity by comparing it with serine 236, another potential phosphorylation site within the DNA binding domain, and demonstrated that phosphorylation of serine 212 confers upon ERalpha a distinct activity regulating gene expression in Huh-7 cells. | Serine | estrogen receptor 1 | Homo sapiens |
| 7 | cDNA microarray and Ingenuity Pathway Analysis, employed on Huh-7 cells ectopically expressing either ERalpha S212A or ERalpha S212D, revealed that phosphorylation of serine 212 enabled ERalpha to regulate a unique set of genes and cellular functions. | Serine | estrogen receptor 1 | Homo sapiens |
| 8 | cDNA microarray and Ingenuity Pathway Analysis, employed on Huh-7 cells ectopically expressing either ERalpha S212A or ERalpha S212D, revealed that phosphorylation of serine 212 enabled ERalpha to regulate a unique set of genes and cellular functions. | Serine | estrogen receptor 1 | Homo sapiens |
| 9 | cDNA microarray and Ingenuity Pathway Analysis, employed on Huh-7 cells ectopically expressing either ERalpha S212A or ERalpha S212D, revealed that phosphorylation of serine 212 enabled ERalpha to regulate a unique set of genes and cellular functions. | Serine | estrogen receptor 1 | Homo sapiens |